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Methylation And How It Causes Cellular Death, Aging And Diseases

Before we start, I'd like to advise that methylation is a good and natural process. In fact, without methylation we would die in just a few days, as methylation is a core process that is required for our entire system to work.

If our body's methylation is not working at its best, it will lead to to many health problems and will definitely accelerate cellular aging and cell death, accelerating the aging process.

first of all, What is methylation?

Methylation is a process where methyl-groups are added to different types of proteins, DNA and other molecules.

It is a normal process and helps to ensure they are in good workign condition. An example is serotonin, the popular "feel good" brain chemical - if it's not methylated, serotonin will just be inactive/deactivated and not be able to function...so our "feel good function" will falter (this can lead to depression)

That's just one of the many chemicals, proteins and DNA in our body that needs to be methylated, and that's why if our body is unable to perform methylation, it will be very, very detrimental to health, and can cause organ and system failures, and even death in severe cases.

Likely the most important methylation process is when it is applied to homocysteine. Homocysteine is a by product of an important amino acid called methionine and is what remains when methionine is used to methylate your proteins and DNA. Homocysteine needs to be methylated to convert it back to methionine. If this process does not happen your body is in for some serious trauma.

Homocysteine is implicated in:

  • Heart disease and stroke by encouraging the sticking/clumping together of platelets
  • Higher levels of oxidized LDL cholesterol from reacting with iron and copper ions to produce a lot of free radicals
  • Dementia and Alzheimer’s
  • Liver Disease
  • Depression
  • Aging in general, in that homocysteine is believed to accelerate the destruction of telomeres

But the above is only one aspect of  methylation

Methylation belonging to certain parts of your DNA can "deactivate" unnecessary genes/genetic factors and can prevent abnormal DNA division.

This means that these abnormalities are not passed on to future generations of cells…a most important component in successful aging, meaning that only the good/best cells are allowed and encouraged to live.

As we age the methylation processes in our bodies start getting less effective and become less efficient with a resulting build up of homocysteine, DNA damage and the development of other flow on effects such as depression.

Which is why if you don’t take pre-emptive and pro-active interventions to ensure sustained and balanced methylation then any hope of a long life free of degenerative diseases is only a far-away  possibility.

As with everything that is related to successful aging, methylation must be balanced. Too much is as bad as too little. Fortunately your body will balance your methylation processes providing that you give it the proper ‘fuel’ to perform the task.

What is this fuel?

There are three groups of compounds that are helpful in methylation with different levels of efficacy.

They are:

  • B Vitamins, B6, B12 and folic acid
  • Tri-Methyl-Glycine TMG, (also known as Betaine), and
  • SAMe.

The B Vitamins are important but more in the capacity of co-factors rather than being a direct solution for methylation in their own right. This is because as we get older these vitamins tend to become a bit ‘sluggish’ and as such progressively less effective.

By far the most effective methylating agent is SAMe which stands for S-Adenosyl-Methionine and is a natural chemical found in all living cells. It is formed in the body by combining the amino acid methionine and ATP (adenosine triphosphate). The science confirming the effectiveness of SAMe as the best methylating agent is indisputable. It can be taken as a supplement but it is not readily available for two reasons. One, is that it MUST be taken in enteric coated form because SAMe is particularly susceptible to stomach acids and two that it is very expensive. We use it in our Neuro-Natural anti aging supplements and in our Total Balance both of which are enteric coated. 

Total Balance anti aging products also contain other effective methylating agents in the form of:

  • B vitamins and folic acid
  • Methionine and ATP
  • Tri-Methyl-Glycine (TMG/Betaine)

Related Articles:

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